Hypercalcemia of malignancy with simultaneous production of parathyroid hormone-related peptide and 1,25-Dihydroxyvitamin D by non-Hodgkin lymphoma: Case report & brief review

We report the case of a 63-year-old man with severe hypercalcemia, acute kidney injury, and concomitant diagnosis germinal center diffuse large B-cell lymphoma (nHL). Hypercalcemia is common finding in patients cancer. Multiple mechanisms can lead to hypercalcemia malignancy, different malignancies are often associated specific mechanism hypercalcemia. Parathyroid hormone-related protein (PTHrP) excessive production 1,25-dihydroxyvitamin D independently (and rarely, concomitantly) development variety malignancies. Literature review related PTHrP co-secretion shows that most reported cases solid tumors responded tumor directed therapy. Our nHL was increased making this an unusual presentation.